Cervical cancer

Name: Cervical cancer

Description: Framework for a 4-stage cervical cancer cascade model, with vital dynamics and new cases

Compartments

Compartment: Source

  • Code name: source
  • Is source
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Without cervical cancer

  • Code name: sus
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Undiagnosed

  • Code name: undx
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Screened

  • Code name: scr
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Diagnosed

  • Code name: dx
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Treated

  • Code name: tx
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Dead (other)

  • Code name: dead
  • Is sink
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Dead (cervical cancer)

  • Code name: dead_cc
  • Is sink
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Characteristics

Characteristic: Population size

  • Code name: alive
  • Value can be used for calibration
  • Includes:
    • Without cervical cancer
    • Undiagnosed
    • Screened
    • Diagnosed
    • Treated
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer

  • Code name: all_people
  • Value can be used for calibration
  • Includes:
    • Undiagnosed
    • Screened
    • Diagnosed
    • Treated
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been screened

  • Code name: all_screened
  • Value can be used for calibration
  • Includes:
    • Screened
    • Diagnosed
    • Treated
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been diagnosed

  • Code name: all_dx
  • Value can be used for calibration
  • Includes:
    • Diagnosed
    • Treated
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: Estimated number of women being treated for cervical cancer

  • Code name: all_tx
  • Value can be used for calibration
  • Includes:
    • Treated
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Parameters

Parameter: Annual number of births

  • Code name: birth_rate
  • Units/format: number
  • Value restrictions: At least 0
  • Contributes to transitions from:
    • “Source” to “Without cervical cancer”
  • Default value: None
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Estimated number of new cervical cancer cases annually

  • Code name: num_acq
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Acquisition rate”
  • Description:
  • Data entry guidance:

Parameter: Acquisition rate

  • Code name: acq_rate
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Without cervical cancer” to “Undiagnosed”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_acq/max(sus,num_acq)
  • Depends on:
    • “Estimated number of new cervical cancer cases annually”
    • “Without cervical cancer”
  • Description:
  • Data entry guidance:

Parameter: Annual number screened

  • Code name: num_screen
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Annual number screened positive”
  • Description:
  • Data entry guidance:

Parameter: Screening yield

  • Code name: screen_yield
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: undx/(undx+sus)
  • Depends on:
    • “Without cervical cancer”
    • “Undiagnosed”
  • Used to compute:
    • “Annual number screened positive”
  • Description:
  • Data entry guidance:

Parameter: Annual number screened positive

  • Code name: pos_screen
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_screen*screen_yield
  • Depends on:
    • “Annual number screened”
    • “Screening yield”
  • Used to compute:
    • “Screening sensitivity”
  • Description:
  • Data entry guidance:

Parameter: Screening sensitivity

  • Code name: screen
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Undiagnosed” to “Screened”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: pos_screen/max(undx,pos_screen)
  • Depends on:
    • “Annual number screened positive”
    • “Undiagnosed”
  • Description:
  • Data entry guidance:

Parameter: Annual number of new diagnoses

  • Code name: num_diag
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Probability of a positive confirmation following screening”
  • Description:
  • Data entry guidance:

Parameter: Probability of a positive confirmation following screening

  • Code name: diag
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Screened” to “Diagnosed”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_diag/max(scr,num_diag)
  • Depends on:
    • “Screened”
    • “Annual number of new diagnoses”
  • Description:
  • Data entry guidance:

Parameter: Annual number newly initiated onto treatment

  • Code name: num_initiate
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Initiation rate”
  • Description:
  • Data entry guidance:

Parameter: Initiation rate

  • Code name: initiate
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Diagnosed” to “Treated”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_initiate/max(dx,num_initiate)
  • Depends on:
    • “Diagnosed”
    • “Annual number newly initiated onto treatment”
  • Description:
  • Data entry guidance:

Parameter: Mortality rate

  • Code name: death
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Without cervical cancer” to “Dead (other)”
    • “Undiagnosed” to “Dead (other)”
    • “Screened” to “Dead (other)”
    • “Diagnosed” to “Dead (other)”
    • “Treated” to “Dead (other)”
  • Default value: 0.015
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Mortality rate for those with untreated cervical cancer

  • Code name: death_cc
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Undiagnosed” to “Dead (cervical cancer)”
    • “Screened” to “Dead (cervical cancer)”
    • “Diagnosed” to “Dead (cervical cancer)”
  • Default value: 0.05
  • Appears in the databook
  • Description:
  • Data entry guidance:

Interactions

Cascades

Cascade: Cervical cancer cascade

  • Description:
  • Stages:
    • All women with cervical cancer
      • Estimated number of women with cervical cancer
    • Ever screened
      • Estimated number of women with cervical cancer who have ever been screened
    • Ever diagnosed
      • Estimated number of women with cervical cancer who have ever been diagnosed
    • Currently treated
      • Estimated number of women being treated for cervical cancer