Diabetes

Name: Diabetes

Description: Framework for a diabetes model, including vital dynamics and new cases

Compartments

Compartment: Source

  • Code name: source
  • Is source
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Susceptible

  • Code name: sus
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Unaware & uncomplicated

  • Code name: unsc_uncomp
  • Value can be used for calibration
  • Appears in the databook
  • Description:
  • Data entry guidance:

Compartment: Unaware & vascular damage

  • Code name: unsc_vd
  • Value can be used for calibration
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Compartment: Screened & uncomplicated

  • Code name: sc_uncomp
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Screened & vascular damage

  • Code name: sc_vd
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Diagnosed & uncomplicated

  • Code name: dx_uncomp
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Diagnosed & vascular damage

  • Code name: dx_vd
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Successful treatment & uncomplicated

  • Code name: txs_uncomp
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Successful treatment & vascular damage

  • Code name: txs_vd
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Treatment failure & uncomplicated

  • Code name: txf_uncomp
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Treatment failure & vascular damage

  • Code name: txf_vd
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Dead (diabetes)

  • Code name: dead_dm
  • Is sink
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Compartment: Dead (other)

  • Code name: dead_other
  • Is sink
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Characteristics

Characteristic: Population size

  • Code name: alive
  • Value can be used for calibration
  • Includes:
    • Susceptible
    • Unaware & uncomplicated
    • Unaware & vascular damage
    • Screened & uncomplicated
    • Screened & vascular damage
    • Diagnosed & uncomplicated
    • Diagnosed & vascular damage
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
    • Treatment failure & uncomplicated
    • Treatment failure & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: All people with T2DM

  • Code name: ch_all
  • Value can be used for calibration
  • Includes:
    • Unaware & uncomplicated
    • Unaware & vascular damage
    • Screened & uncomplicated
    • Screened & vascular damage
    • Diagnosed & uncomplicated
    • Diagnosed & vascular damage
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
    • Treatment failure & uncomplicated
    • Treatment failure & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: People screened for T2DM

  • Code name: ch_screened
  • Value can be used for calibration
  • Includes:
    • Screened & uncomplicated
    • Screened & vascular damage
    • Diagnosed & uncomplicated
    • Diagnosed & vascular damage
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
    • Treatment failure & uncomplicated
    • Treatment failure & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: People diagnosed with T2DM

  • Code name: ch_diag
  • Value can be used for calibration
  • Includes:
    • Diagnosed & uncomplicated
    • Diagnosed & vascular damage
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
    • Treatment failure & uncomplicated
    • Treatment failure & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: People treated for T2DM

  • Code name: ch_tx
  • Value can be used for calibration
  • Includes:
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
    • Treatment failure & uncomplicated
    • Treatment failure & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: People with HbA1c control

  • Code name: ch_succ
  • Value can be used for calibration
  • Includes:
    • Successful treatment & uncomplicated
    • Successful treatment & vascular damage
  • Appears in the databook
  • Databook values will be used for model initialization
  • Description:
  • Data entry guidance:

Characteristic: Proportion screened for T2DM

  • Code name: ch_propscreened
  • Includes:
    • People screened for T2DM
  • Denominator: All people with T2DM
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Characteristic: Proportion diagnosed with T2DM

  • Code name: ch_propdiag
  • Includes:
    • People diagnosed with T2DM
  • Denominator: All people with T2DM
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Characteristic: Proportion treated for T2DM

  • Code name: ch_proptx
  • Includes:
    • People treated for T2DM
  • Denominator: All people with T2DM
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Characteristic: Proportion with HbA1c control

  • Code name: ch_propsucc
  • Includes:
    • People with HbA1c control
  • Denominator: All people with T2DM
  • Does not appear in the databook
  • Description:
  • Data entry guidance:

Parameters

Parameter: Annual number of births

  • Code name: birth_rate
  • Units/format: number
  • Value restrictions: At least 0
  • Contributes to transitions from:
    • “Source” to “Susceptible”
  • Default value: 15828
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Estimated number of new diabetes cases annually

  • Code name: num_acq
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Acquisition rate”
  • Description:
  • Data entry guidance:

Parameter: Acquisition rate

  • Code name: acq_rate
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Susceptible” to “Unaware & uncomplicated”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_acq/max(sus,num_acq)
  • Depends on:
    • “Estimated number of new diabetes cases annually”
    • “Susceptible”
  • Description:
  • Data entry guidance:

Parameter: Time before progression to vascular damage

  • Code name: prog_rate
  • Units/format: duration
  • Value restrictions: At least 0
  • Contributes to transitions from:
    • “Unaware & uncomplicated” to “Unaware & vascular damage”
    • “Screened & uncomplicated” to “Screened & vascular damage”
    • “Diagnosed & uncomplicated” to “Diagnosed & vascular damage”
    • “Treatment failure & uncomplicated” to “Treatment failure & vascular damage”
  • Default value: 1
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Annual number screened

  • Code name: num_screen
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Annual number screened positive”
  • Description:
  • Data entry guidance:

Parameter: Yield among those screened

  • Code name: screen_yield
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: (unsc_uncomp+unsc_vd)/(unsc_uncomp+unsc_vd+sus)
  • Depends on:
    • “Unaware & uncomplicated”
    • “Susceptible”
    • “Unaware & vascular damage”
  • Used to compute:
    • “Annual number screened positive”
  • Description:
  • Data entry guidance:

Parameter: Annual number screened positive

  • Code name: pos_screen
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_screen*screen_yield
  • Depends on:
    • “Annual number screened”
    • “Yield among those screened”
  • Used to compute:
    • “Screening sensitivity”
  • Description:
  • Data entry guidance:

Parameter: Screening sensitivity

  • Code name: screen
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Unaware & uncomplicated” to “Screened & uncomplicated”
    • “Unaware & vascular damage” to “Screened & vascular damage”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: pos_screen/max(unsc_uncomp+unsc_vd,pos_screen)
  • Depends on:
    • “Unaware & uncomplicated”
    • “Annual number screened positive”
    • “Unaware & vascular damage”
  • Description:
  • Data entry guidance:

Parameter: Annual number of new diagnoses

  • Code name: num_diag
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Diagnosis sensitivity”
  • Description:
  • Data entry guidance:

Parameter: Diagnosis sensitivity

  • Code name: diag
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Screened & uncomplicated” to “Diagnosed & uncomplicated”
    • “Screened & vascular damage” to “Diagnosed & vascular damage”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_diag/max(sc_uncomp+sc_vd,num_diag)
  • Depends on:
    • “Screened & vascular damage”
    • “Annual number of new diagnoses”
    • “Screened & uncomplicated”
  • Description:
  • Data entry guidance:

Parameter: Annual number newly initiated onto treatment

  • Code name: num_initiate
  • Units/format: number
  • Value restrictions: At least 0
  • Default value: None
  • Appears in the databook
  • Used to compute:
    • “Initiation rate”
  • Description:
  • Data entry guidance:

Parameter: Initiation rate

  • Code name: initiate
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Diagnosed & uncomplicated” to “Successful treatment & uncomplicated”
    • “Diagnosed & vascular damage” to “Successful treatment & vascular damage”
  • Default value: None
  • Does not appear in the databook
  • This parameter’s value is computed by a function: num_initiate/max(dx_uncomp+dx_vd,num_initiate)
  • Depends on:
    • “Diagnosed & uncomplicated”
    • “Diagnosed & vascular damage”
    • “Annual number newly initiated onto treatment”
  • Description:
  • Data entry guidance:

Parameter: Treatment failure rate

  • Code name: treat_fail
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Successful treatment & uncomplicated” to “Treatment failure & uncomplicated”
    • “Successful treatment & vascular damage” to “Treatment failure & vascular damage”
  • Default value: 0.5
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Proportion of those experiencing treatment failure who are offered support

  • Code name: treat_suc
  • Value can be used for calibration
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Treatment failure & uncomplicated” to “Successful treatment & uncomplicated”
    • “Treatment failure & vascular damage” to “Successful treatment & vascular damage”
  • Default value: None
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Death rate for diabetes with vascular damage

  • Code name: death_vd
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Unaware & vascular damage” to “Dead (diabetes)”
    • “Screened & vascular damage” to “Dead (diabetes)”
    • “Diagnosed & vascular damage” to “Dead (diabetes)”
    • “Successful treatment & vascular damage” to “Dead (diabetes)”
    • “Treatment failure & vascular damage” to “Dead (diabetes)”
  • Default value: 0.025
  • Appears in the databook
  • Description:
  • Data entry guidance:

Parameter: Background mortality rate

  • Code name: death_other
  • Units/format: probability
  • Value restrictions: 0-1.0000
  • Contributes to transitions from:
    • “Susceptible” to “Dead (other)”
    • “Unaware & uncomplicated” to “Dead (other)”
    • “Unaware & vascular damage” to “Dead (other)”
    • “Screened & uncomplicated” to “Dead (other)”
    • “Screened & vascular damage” to “Dead (other)”
    • “Diagnosed & uncomplicated” to “Dead (other)”
    • “Diagnosed & vascular damage” to “Dead (other)”
    • “Successful treatment & uncomplicated” to “Dead (other)”
    • “Successful treatment & vascular damage” to “Dead (other)”
    • “Treatment failure & uncomplicated” to “Dead (other)”
    • “Treatment failure & vascular damage” to “Dead (other)”
  • Default value: 0.015
  • Appears in the databook
  • Description:
  • Data entry guidance:

Interactions

Cascades

Cascade: Diabetes care cascade

  • Description:
  • Stages:
    • All people with T2DM
      • Unaware & uncomplicated
      • Unaware & vascular damage
      • Screened & uncomplicated
      • Screened & vascular damage
      • Diagnosed & uncomplicated
      • Diagnosed & vascular damage
      • Successful treatment & uncomplicated
      • Successful treatment & vascular damage
      • Treatment failure & uncomplicated
      • Treatment failure & vascular damage
    • Screened
      • Screened & uncomplicated
      • Screened & vascular damage
      • Diagnosed & uncomplicated
      • Diagnosed & vascular damage
      • Successful treatment & uncomplicated
      • Successful treatment & vascular damage
      • Treatment failure & uncomplicated
      • Treatment failure & vascular damage
    • Diagnosed
      • Diagnosed & uncomplicated
      • Diagnosed & vascular damage
      • Successful treatment & uncomplicated
      • Successful treatment & vascular damage
      • Treatment failure & uncomplicated
      • Treatment failure & vascular damage
    • Treated
      • Successful treatment & uncomplicated
      • Successful treatment & vascular damage
      • Treatment failure & uncomplicated
      • Treatment failure & vascular damage
    • HbA1c control
      • Successful treatment & uncomplicated
      • Successful treatment & vascular damage

Cascade: Diabetes care cascade - vascular damage

  • Description:
  • Stages:
    • All people
      • Unaware & vascular damage
      • Screened & vascular damage
      • Diagnosed & vascular damage
      • Successful treatment & vascular damage
      • Treatment failure & vascular damage
    • Screened
      • Screened & vascular damage
      • Diagnosed & vascular damage
      • Successful treatment & vascular damage
      • Treatment failure & vascular damage
    • Diagnosed
      • Diagnosed & vascular damage
      • Successful treatment & vascular damage
      • Treatment failure & vascular damage
    • Treated
      • Successful treatment & vascular damage
      • Treatment failure & vascular damage
    • HbA1c control
      • Successful treatment & vascular damage

Cascade: Diabetes care cascade - uncomplicated cases

  • Description:
  • Stages:
    • All people
      • Unaware & uncomplicated
      • Screened & uncomplicated
      • Diagnosed & uncomplicated
      • Successful treatment & uncomplicated
      • Treatment failure & uncomplicated
    • Screened
      • Screened & uncomplicated
      • Diagnosed & uncomplicated
      • Successful treatment & uncomplicated
      • Treatment failure & uncomplicated
    • Diagnosed
      • Diagnosed & uncomplicated
      • Successful treatment & uncomplicated
      • Treatment failure & uncomplicated
    • Treated
      • Successful treatment & uncomplicated
      • Treatment failure & uncomplicated
    • HbA1c control
      • Successful treatment & uncomplicated